Keywords: Alzheimer's, electrophysiology, epilepsy, hippocampus, inhibitory cell, interneuron, ion channel, mathematical model, memory, network, model database, neural networks and dynamics, NEURON software, nonlinear dynamics oscillator, rhythm, schizophrenia, sleep, synaptic plasticity, synaptic transmission, synapse.
Detailed Description: Our lab develops and analyzes mathematical models of neurons and neuronal networks. Our present emphases are on the diverse, heterogeneous nature of inhibitory interneurons in hippocampus, on cellular-based mechanisms generating and controlling (rhythmic) population network output in hippocampus, and on (model and experimental) data analyses to examine underlying mechanisms.
Given the importance of the hippocampus in learning and memory and the multitude of experimental investigations and neurological conditions involving the hippocampus, our long-term goal is to use our developed models to help determine cellular and network mechanistic disruptions that underlie various neurological conditions (e.g., Alzheimer’s, epilepsy, schizophrenia etc.).
Procedures: computer modeling, mathematical modeling, mathematical analyses, data analyses (MATLAB), specialized software (NEURON, Brian, XPPAUT)
High performance computing (e.g., SciNet), Neuroscience Gateway (NSG)
Alexandra (Pierri) Chatzikalymniou
Within the Department of Physiology
Outside of the Department of Physiology Sylvain Williams (McGill University, Douglas Mental Health Institute)
Sylvain Williams (McGill University, Douglas Mental Health Institute)
Liang Zhang (TWRI)
Josh Lawrence (University of Montana)
Emily Stone (Math, University of Montana)
Sue Ann Campbell (Applied Math, University of Waterloo)
Lisa Topolnik (Laval)
PRESENT GRANT COMMITTEES SERVED ON
Agency: NSERC Review Panel (till 2013)
Agency: Compute Canada
Committee: Bioinformatics, Neuroscience and Medical Imaging Review Committee (2012, 2013, 2014)