This course is one of a set of five advanced seminar half-credit courses dealing with current research areas in the cardiovascular system. Specifically, JCV3064H will provide a translational perspective on Microvascular medicine and progress from new molecular concepts of microvascular function to evaluating their clinical applicability and therapeutic value.
Areas that may be covered include:
Microvascular endothelial function and dysfunction
Molecular signaling in the Microvascular smooth muscle – specific focus on myogenic responsiveness
Microcirculation in the lung
Molecular mechanisms underlying Microvascular dysfunction following subarachnoid hemorrhage
Aging microcirculation
Diabetes-associated Microvascular dysfunction
Microvascular function during general anaesthesia
Circadian rhythmicity in microvascular function
Phenomenon of neovascularization
New experimental platforms to assess microvascular function
Overview of recent clinical trials on therapeutic strategies targeting the function and/or structure of the microcirculation
Prerequisite:
None
Enrolment:
Graduate students interested in heart research. Preference will be given to students enrolled in the Cardiovascular Sciences Collaborative Program.
Evaulation:
10% essay outline
30% student presentation – oral presentation on final term paper
40% final essay – subject dealing with a lecture topic
15% student seminar contributions and participation
5% attendance
