P.W. Frankland, Ph.D.
|Address:||Dr. Paul Frankland
Program in Integrative Biology
Hospital for Sick Children Research Institute
555 University Ave.
Toronto, Ontario M5G 1X8
ACADEMIC STATUSDepartmental Status: Associate Professor
Primary/Cross-appointments: Primary: Psychology; Cross-Appointment: IMS
Degrees: Ph.D, 1996
Affiliations: Program in Neurosciences & Mental Health, HSC.
RESEARCHResearch Divisions: Brain Research and Integrated Neurophysiology
Research Interests: Mouse genetic models of cognitive function and dysfunction.
Keywords: Learning/ memory/ genetically-engineered mice/ hippocampus/ cortex/ adult neurogenesis.
The general goal of our research program is to understand how our brains normally encode, store and retrieve information. By combining mouse-genetic, molecular biology, immunohistochemical and behavioral approaches we currently focus on two major questions: First, to understand how memories are initially encoded in the hippocampus, and, in particular, how adult neurogenesis might contribute to this process; Second, to understand how these memories are subsequently transformed into lifelong (or remote) memories in the cortex for long-term storage. Understanding how these basic processes work is an essential stepping stone in developing more effective treatment strategies for memory dysfunction, whether associated with normal aging, disorders such as Alzheimer’s disease, or resulting from stroke or trauma.
METHODS USEDCell and tissue culture: Hippocampal cells, neurons.
Procedures: Behavioural tests, immunohistochemistry, micro and macrostimulation of peripheral nerves and central brain structures, western blot.
EQUIPMENT USEDBlotting apparatus, confocal microscope, culture hood, culture incubators, cryostat, fluorescence microscope, fresh tissue sectioning systems, gel apparatus, infusion apparatus, low- and high-speed centrifuge, low and ultralow freezers, microwave oven, mini vortexer, rat running wheels, vibratome, water baths.
SAMPLE PUBLICATIONS AND ABSTRACTSClick on link to PubMed
PRESENT TRAINEESGrad students: