P.W. Frankland, Ph.D.
Dr. Frankland
Contact Information:
Phone: 416-813-7654 x1823
Fax:

416-813-7717

Email: paul.frankland@sickkids.ca
Webpage:

http://www.franklandlab.com/

Address: Dr. Paul Frankland
Program in Integrative Biology
Hospital for Sick Children Research Institute
555 University Ave.
Toronto, Ontario
M5G 1X8

ACADEMIC STATUS
Departmental Status: Associate Professor

Primary/Cross-appointments: IMS

Degrees: Ph.D, 1996

Affiliations: Program in Neurosciences & Mental Health, HSC.

RESEARCH
Research Divisions: Brain Research and Integrated Neurophysiology

Research Interests: Mouse genetic models of cognitive function and dysfunction.

Keywords: Learning/ memory/ genetically-engineered mice/ hippocampus/ cortex/ adult neurogenesis.

Detailed Description:
The general goal of our research program is to understand how our brains normally encode, store and retrieve information. By combining mouse-genetic, molecular biology, immunohistochemical and behavioral approaches we currently focus on two major questions: First, to understand how memories are initially encoded in the hippocampus, and, in particular, how adult neurogenesis might contribute to this process; Second, to understand how these memories are subsequently transformed into lifelong (or remote) memories in the cortex for long-term storage. Understanding how these basic processes work is an essential stepping stone in developing more effective treatment strategies for memory dysfunction, whether associated with normal aging, disorders such as Alzheimer’s disease, or resulting from stroke or trauma.

METHODS USED
Cell and tissue culture: Neurons.

Procedures: Behavioural tests, micro and macrostimulation of peripheral nerves and central brain structures, western blot.

EQUIPMENT USED
Blotting apparatus, confocal microscope, culture hood, culture incubators, cryostat, fluorescence microscope, fresh tissue sectioning systems, gel apparatus, infusion apparatus, low- and high-speed centrifuge, low and ultralow freezers, microwave oven, mini vortexer, rat running wheels, vibratome, water baths.

SAMPLE PUBLICATIONS AND ABSTRACTS
Click on link to PubMed

PRESENT TRAINEES
Grad students:
Afra Wang
Anne Wheeler
Adam Santoro
Alonso Martinez-Canabal
Maithe Arruda-Carvalho

PDFs:
Blake Richards
Leonardo Restivo
Yosuke Niibori
Katherine Akers
Loren DeVito
Jon Epp