Molecular and Cellular Biology of Lipoprotein Metabolism in Health and Disease
Khosorw Adeli’s basic research program is focused on the link between insulin resistant diabetes and dysregulation of lipoprotein metabolism. His group has been elucidating the molecular mechanisms linking diet-induced insulin resistance and metabolic dyslipidemia. His laboratory is employing animal models of insulin resistance to investigate the molecular mechanisms mediating the diabetogenic effect of fructose-rich diets, mechanisms of fructose-induced hepatic insulin resistance, and pathways leading to hepatic and intestinal lipogenesis and lipoprotein dysregulation.
Development of a Pediatric Reference Interval Database for Disease Biomarkers
Dr. Adeli has also been spearheading a national initiative CALIPER (Canadian Laboratory Initiative on Paediatric Reference Intervals) in collaboration with other pediatric health centres across Canada to establish a comprehensive database of pediatric reference intervals for laboratory biomarkers of pediatric disease.
CALIPER Reference Interval Database: Dr. Adeli has developed an online database for paediatric reference intervals . This database is continually updated as research produces new reference values for bio-markers of paediatric disease. The CALIPER database has been accepted worldwide as the most up to date pediatric reference resource available anywhere.
CALIPER Mobile App: This is the first mobile app developed by Dr. Adeli’s laboratory along with SickKids by the Research Institute’s IT team. The CALIPER App is a Smartphone app developed to provide pediatricians, family physicians, and other healthcare professionals with easy access to a reference database that will assist with result interpretation of medical tests done on children and adolescents. It provides ready access to a comprehensive and up to date pediatric reference interval database that allows accurate test result interpretation. The app provides reference intervals for over 60 tests routinely performed on children.
Gary Lewis, Tony Lam, Patricia Brubaker, Daniel Drucker
Animal (hamster, mice, rats) whole body physiology, ex vivo primary cell culture, in vivo peripheral and central infusion studies, biochemical methods,
Ultracentrige, general lab equipment, surgical tools, access to imaging facility and real time PCR systems, ELISA reader, and other minor equipment
Bogdan Stankovic, MSc. candidate
Houman Tahmasebi, MSc. candidate
Danielle Alvarez, MSc. candidate
Victoria Higgins, PhD. candidate
Central nervous system regulation of hepatic lipid and lipoprotein metabolism. Taher J, Farr S, Adeli K. Curr Opin Lipidol. 2017 Feb;28(1):32-38.
Pediatric Metabolic Syndrome: Pathophysiology and Laboratory Assessment. Higgins V, Adeli K. EJIFCC. 2017 Mar 8;28(1):25-42.
The Canadian laboratory initiative on pediatric reference intervals: A CALIPER white paper. Adeli K, Higgins V, Trajcevski K, White-Al Habeeb N. Crit Rev Clin Lab Sci. 2017 Oct 11:1-56. doi: 10.1080/10408363.2017.1379945. [Epub ahead of print]
High serum serotonin in sudden infant death syndrome. Haynes RL, Frelinger AL 3rd, Giles EK, Goldstein RD, Tran H, Kozakewich HP, Haas EA, Gerrits AJ, Mena OJ, Trachtenberg FL, Paterson DS, Berry GT, Adeli K, Kinney HC, Michelson AD. Proc Natl Acad Sci U S A. 2017 Jul 18;114(29):7695-7700.
Complex role of autophagy in regulation of hepatic lipid and lipoprotein metabolism. Zamani M, Taher J, Adeli K. J Biomed Res. 2017 Sep 26;31(5):377-385.